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Akut Antikor Aracılı Renal Allograt Rejeksiyonunda Çift Filtrasyon Plazmaferez: Üç Vaka Bildirimi

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Utility of Double Filtration Plasmapheresis in Acute Antibody Mediated Renal Allograft Rejection: Report of Three Cases

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Sayfa Aralığı:: 
301-303

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Abstract (Original Language): 
Plazmaferez, dolaşımdaki antikor, immün kompleks ve toksin düzeylerini hızla düşürmek için kullanılan bir ekstrakorporeal yöntemdir.İki tip plazmaferez bulunmaktadır: Santrifüj ve membran fi ltrasyonu ile yapılan regüler plazmaferez (RP) ve büyük moleküllerin daha selektif olarak fi ltre edildiği, plazma ayırıcısı ve plazma fraksiyoneri olarak adlandırılan iki membranın kullanıldığı özel bir fi ltrasyon şekli olan çift fi ltrasyon plazmaferezdir (ÇFP).ÇFP’nin RP’ye göre bazı avantajları vardır. ABO uyumsuzluğunda böbrek nakli uygulamasında ÇFP yaygın olarak kullanılmasına rağmen, ÇFP’nin faydalı etkileri için iyi bir aday olabilecek antikor aracılı akut renal allograft rejeksiyonu olan hastalarda ÇFP ile ilgili vaka bildirimi yoktur. Burada rejeksiyon tedavisinin bir parçası olarak ÇFP uygulanan üç renal transplant hastasını bildirmekteyiz.
Abstract (2. Language): 
Plasmapheresis is an extracorporeal procedure, which is often employed to rapidly lower circulating titers of autoantibodies, immune complexes or toxins. There are two types of plasmapheresis namely, regular plasmapheresis (RPP) by centrifugation and membrane fi ltration, and double fi ltration plasmapheresis (DFPP) which is a special form of membrane fi ltration in which two membranes called as plasma separator and plasma fractionator are employed to fi lter macromolecules more selectively. DFPP have several advantages over RP. Despite widespread utilization of DFPP in the setting of ABO blood group incompatible kidney transplantation, there is no report regarding DFPP in patients with antibody mediated acute renal allograft rejection who are good candidates for benefi cial effects of DFPP. Here we report three renal transplant recipients in whom DFPP was applied as a component of anti-rejection treatment regimen.

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DOI: 
10.5262/tndt.2011.1003.17

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