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Hemodiyaliz Hastalarında Depresyon Serum Lipid Düzeyleri ile İlişkili mi?

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Are Serum Lipid Levels Associated With Depression in Hemodialysis Patients?

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106-110

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Abstract (Original Language): 
Amaç: Yakın zamanda yapılan bazı çalışmalarda serum lipid düzeyleri ile depresyon arasında ilişki saptanmıştır. Çalışmamızda he¬ modiyalize giren hastalarda serum lipid düzeyleri ile depresyon ara¬ sındaki ilişkiyi araştırmayı amaçladık. Yöntem ve gereçler: Çalışmaya Yüzüncü Yıl Üniversitesi Tıp Fakültesi Eğitim Hastanesi Hemodiyaliz Ünitesi'nde Ağustos 2000-Haziran 2001 arasında hemodiyalize giren hastalar dahil edildi. Hemodiyaliz hastalarında serum total kolesterol, yüksek yoğunluklu kolesterol (HDL), düşük yoğunluklu kolesterol (LDL), trigliserid ve çok düşük yoğunluklu kolesterol (VLDL) düzeyleri ile depresyon arasında ilişki araştırıldı. Depresyon düzeyi Beck Depresyon indeksi (BDİ) ile ölçüldü. Diyabetik hastalar çalışma dışı bırakıldı. Bulgular: Çalışmaya 25'i erkek, 21'i kadın, yaş ortalaması 45.2 ± 16.3 (15-73 yaş) yıl olan 46 hasta dahil edildi. Ortalama hemodiyaliz süresi 28 ± 30.2 ay idi. Ortalama Kt/V 1.2 ± 0.4 idi. Ortalama serum albümin değeri 3.63 ± 0.55 (2.5-4.7) g/dL, ortalama BDİ 15.9 ± 6.2 (4¬ 31) idi. Serum TK, LDL ve HDL ile depresyon arasında ilişki saptanırken (sırasıyla p değeri ve Pearson korelasyon katsayısı 0.002, 0.006, 0.563; -0.439, -0.403, -0.087 idi.); TG ve VLDL düzeyleri ile depresyon arasında saptanmadı (p değeri 0.096 ve 0.091, korelasyon katsayısı - 0.249 ve -0.252 idi). Sonuç: Depresyon, hemodiyaliz hastalarında en sık görülen psikolojik bulgudur. Çalışmamızda serum TK, HDL, LDL düzeyleri ile depresyon arasında zıt yönlü bir ilişki varken, TG ve VLDL düzeyleri ile depresyon arasında ilişki saptanmadı.
Abstract (2. Language): 
Background: Recent study suggested a relation between low levels of serum lipids and depression. The aim of this study was to as¬ sess the association between serum lipid levels and depression in patients with end-stage renal disease (ESRD). Methods: All the patients who were attending Yüzüncü Yil University Faculty of Medicine Training Hospital Hemodialysis Unit, in Turkey, from August 2000 to July 2001, were prospectively studied. Serum TC, LDL-c, HDL-c, VLDL-c and triglyceride levels were measured and Beck Depression Inventory (BDI) was administered to all patients. Diabetic patients were excluded. Results: There were 46 patients (25 males and 21 females). Me¬ an duration of hemodialysis was 28.1 ± 30.2 months. Mean Kt/V was 1.2 ± 0.4. The mean age of study group was 45.2 ± 16.3 years and the age range was 15-73 years. Mean serum albumin concentration was 3.63 ± 0.55 (2.5-4.7) g/dL. The patients' mean BDI was 15.9 ± 6.2 (4¬ 31). There was association between serum TC (total cholesterol), LDL-c (low density lipoprotein cholesterol), HDL-c (high density lipoprotein cholesterol) and depression but no association between serum VLDL-c (very-low density lipoprotein cholesterol) and triglyceride levels and depression in patients with ESRD. Conclusion: Depression is the most common psychological fin¬ ding in patients with ESRD. Our study demonstrate that there were associations between low serum TC, LDL-c, HDL-c levels and depres¬ sion but there was no association between depression and serum triglyceride and VLDL-c levels in patients with ESRD.

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