BEŞYÜZ ONÜÇ BÖBREK BİYOPSİSİNİN KLİNİKOPATOLOJİK AÇIDAN DEĞERLENDİRİLMESİ

Article Title (2.Language): 

EVALUATION OF CLINICOPATHOLOGICAL FINDINGS OF 513 KIDNEY BIOPSIES

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  • 2005

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  • 68

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  • 2

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43-45

Article Language: 

  • Türkçe

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Abstract (Original): 

ÖZET Amaç: Böbrek biyopsisi, renal parenkimal hastal›klar›n tan›s›nda ve tedavisinin belirlenmesinde kullan›lan bir yöntemdir. Bu çal›flmada böbrek biyopsisinin klinikopatoloji aç›s›ndan de¤erlendirilmesi amaçlanm›flt›r. Gereç ve yöntem: Bu çal›flmada Kas›m 1999 ile May›s 2004 aras›nda Nefroloji Bilim Dal› servisinde gerçeklefltirilmifl olan 513 böbrek biyopsisi de¤erlendirilmeye al›nm›flt›r. Biyopsilerin 444’ü (%86,5) nativ böbreklere ait iken, 69’u (%13,5) transplant biyopsisiydi. Bulgular: Nativ böbrek biyopsileri içinde en s›k endikasyon nefrotik sendrom (n=140, %31,5) idi. Bunu patolojik idrar bulgusu (proteinüri ve hematüri) (n=116, %26,1) ve lupus nefriti (n=78, %17,6) izlemekteydi. En s›k konan tan› lupus nefriti (n=54, %12,2) iken bunu IgA nefropatisinin (n=53, %11,9) ve kresentik glomerulonefritin (n=51, %11,5) takip etti¤i görüldü. Transplant biyopsileri içinde en s›k karfl›lafl›lan tan›n›n kronik allograft nefropatisi (n=38, %55,1) oldu¤u dikkati çekti. Sonuç: Sonuç olarak, 513 böbrek biyopsisinin de¤erlendirildi¤i bu çal›flmada, en s›k böbrek biyopsisi endikasyonunun nefrotik sendrom oldu¤u, primer glomeruler hastal›klar içinde en s›k IgA nefropatisi ile, sekonder glomeruler hastal›klar içinde ise en s›k lupus nefriti ile karfl›lafl›ld›¤› dikkati çekmifltir.

Abstract (English): 

Objective: Kidney biopsy is performed for the diagnosis and the decision of treatment of renal parenchymal diseases. The aim of this study was to evaluate the clinicopathological findings of kidney biopsies. Materials and methods: 513 kidney biopsies performed between November 1999 and May 2004 at the Division of Nephrology were included in the study. 444 (86.5%) of the biopsies were from native kidneys, while 69 (13.5%) were from transplant kidneys. Results: The most common indication for biopsy of native kidneys was nephrotic syndrome (n=140, 31.5%). This was followed by pathological urinary findings (proteinuria and hematuria) (n=116, 26.1%) and lupus nephritis (n=78, 17.6%). The most common diagnosis was lupus nephritis (n=54, 12.2%) which was followed by IgA nephropathy (n=53, 11.9%) and crescentic glomerulonephritis (n=51, 11.5%). The most common diagnosis of transplant biopsies was chronic allograft nephropathy (n=38, 55.1%). Conclusion: In conclusion, the present study which evaluated 513 renal biopsies showed that nephrotic syndrome was the most common indication for kidney biopsy. IgA nephropathy was the most common primary glomerular disease and lupus nephritis was the most common secondary glomerular disease among the biopsies.

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References: 

1. Chan KW, Chan TM, Cheng IKP. Clinical and pathological characteristics
of patients with glomerular diseases at a university teaching
hospital: 5-year prospective review. Hong Kong Med J
1999; 5:240-244.
2. Gesualdo L, Di Palma AM, Morrone LF, Strippoli GF, Schena
FP, on behalf of the Italian Immunopathological Group, Italian
Society of Nephrology. The Italian experience of the national registry

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