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This study was designed to determine the antiulcer activity of n-butanol soluble fractions of Albizzia lebbeck bark and leave in pylorus ligation, ethanol and Indomethacin induced models in rats. The various extracts were prepared and extracts containing flavanoids, tannins and saponins (Methanolic extract) was selected for isolation of chemical constituents. n- butanol soluble fractions of Albizzia Lebbeck bark extract (BFALB) and leaf extract (BFALL) were selected for further study. Both fractions were subjected to acute toxicity study. The 60 mg/Kg BFALB and 20 mg/Kg BFALL were selected. In pylorus ligation induced ulcer model, the parameters studied were gastric volume, pH, free acidity, total acidity and ulcer index. Ulcer index was also determined in ethanol and Indomethacin induced ulcer models. Pretreatment with BFALB and BFALL have shown decrease in ulcer index in all the experimental models of ulcer. The prior administration of both the fractions also reduced the total acidity, free acidity and increased the pH. However, the gastric volume was not reduced with 60 mg/kg of BFALB and significantly reduced with 20 mg/kg of BFALL (p<0.001). These results suggest that the antiulcerogenic compound(s) present in methanolic extract of Albizzia Lebbeck bark and leave may be clustered in the n-butanol fraction, which will be investigated for the probable mechanisms of action.
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