ERKEK İNFERTİLİTESİNDE HİPERPROLAKTİNEMİNİN SEMEN PARAMETRELERİ ÜZERİNE ETKİSİ

Yayın Yılı: 
1998
Cilt: 
29
Sayı: 
2
Sayfa Aralığı:: 
95-98
Yayın Dili: 
Türkçe
Abstract (2. Language): 
The effect of prolactin (PRL) on spermatogenesis and semen parameters is not known well. To determine the relation between hyperprolactinemia and spermatogenesis we evaluated 85 infertile patients with hyperprolactinemia. We anaiysed the serum PRL, follicle-stimulating hormone, luteinizing hormone, total testosterone levels and obtained at least two semen anaiyses in all cases. Results.- In patients using bromocryptine mesylate for hyperprolactinemia, serum PRL levels returned to normal levels within 4 months, but semen analyse parameters did not differ from baseline values. Conclusion.- Hyperprolactinemia has a small effect on sperm density, motility and morphology. Bromocryptine mesylate offers no additive therapeutic effect for the hyperprolactinemia in male infertility.
Özet (Orjinal Dil): 
Prolaktinin (PRL) spermatogenez ve sperm parametreleri üzerine olan etkisi henüz kesinleşmemiştir. İnfertilite olgularında hiperprolaktinemi ve spermatogenez arasındaki ilişkiyi değerlendirmek amacı ile 85 infertil ve hiperprolaktinemili hastayı araştırdık. Olgularımızın hepsinde serum PRL, folikül stimülan hormon, luteinizan hormon, total testosteron düzeyi tayinleri ve en az iki semen analizi yapılmıştır. Hiperprolaktinemi saptanan olgularda bromokriptin mesilat tedavisine başlanmış ve 2-4 aylık bir süre sonunda PRL düzeyleri normale dönmüş, ancak bu durum semen analizi parametrelerine yansımamıştır. Sonuç olarak hiperprolaktineminin sperm sayı, morfolojisi ve motilitesine etkisinin az olduğunu ve tedavisinin erkek infertilitesi tedavisinde katkısının anlamlı olmadığını saptadık.
Referanslar: 

1. Zipf WB, Payne AF, Kelch RP. Prolactin, growth hormone, and luteinizing hormone in the maintenance of testicular luteinizing hormone receptors. Endocrinology 1978:103: 595-600.
2. Gonzales GF, Garcia-Hjarles M, Velasquez G. Hyperprolactinemia and hyperserotoninaemia: Their relationship to seminal quallty. Andrologia 1992: 24: 95-100.
3. Eggert-Kruse W, Schwalbach B, Gerhard I, Tilgen W, Runnebaum B. Influence of serum prolactin on semen characteristics and sperm function. Int J Fertil 1991: 36: 234-251.
4. WHO laboratory manual for the examination of human and sperm-cervical mucus interaction. 3rd edition, Cambridge University Press, 1992.
5. Hafiez AA, Lloyd CW, Bartke A. The role of proactin in the regulation of testis function: The effects of prolactin and luteinizing hormone on the plasma levels of testosterone and androstenedione in hypophysectomized rats. J Endocrinol 1974: 52: 327-332.
6. Segal S, Polishuk WZ, Ben-David M. Hyperprolactinemia male infertility. Fertil Steril 1976: 27: 1425-1427.
7. Smith ML, Luqman WA, Rakoff JS. Correlations between seminal radioimmunoreactive prolactin, sperm count and sperm motility in prevasectomy and infertility clinic patients. Fertil Steril 1979: 32: 312-315.
8. Spark RF, Wills CA, O'Rellly G, Ransil BJ, Bergland R. Hyperprolactinemia in males with and without pituary macroadenomas. Lancet 1982: 17: 129-132.
9. Sadi K, Wenn RV, Sharif F. Bromocriptine for male infertility. Lancet 1977: 1: 250-251.

Thank you for copying data from http://www.arastirmax.com