Metoklopramid Premedikasyonunun Vekuronyum ve Mivakuryum ile Sağlanan Nöromüsküler Blok Üzerindeki Etkisi

Makalenin İngilizce İsmi: 
The Effects of Metoclopramide Premedication on the Neuromuscular Blockade of Vecuronium and Mivacurium
Makale İçerik Bilgileri
Makale Dili: 
Türkçe
Anahtar Kelimeler: 
Nöromüsküler blok
metoklopramid
vekuronyum
mivakuryum.
Key Words: 
Metoclopramide
vecuronium
mivacurium
İngilizce Özet: 

Elimination of metoclopramide is mostly made by cholinesterase enzyme. Especially cholinesterase enzyme took place
at the cessation of the effects of depolarisating neuromuscular blocking agents. Cholinesterase enzyme levels can differentiate
with metoclopramide administration. In this study we compared the effect of metoclopramide premedication with vecuronium
and mivacurium's neuromuscular effects. Eighty patients undergoing elective general surgery operations were enrolled to
the study. The patients were grouped according to the premedication of metoclopramide and to the neuromusculary blocking
agent used as Group Metoclopramide-Mivacurium (n = 20), Group Mivacurium (n = 20), Group Metoclopramide-Vecuronium
(n = 20), and Group Vecuronium (n = 20). The neuromuscular blockage was measured by accelomyography (TOF Guard),
time to maximum blockage (sn), T25 (min.), T75 (min.), and recovery index (T25-T75) (min.) was enrolled. Student's t test,
chi-square, repeated measures of ANOVA, posthoc Tukey-Kramer tests were used for statistical analysis. P < 0.05 values were
accepted as statistically significant. There were no significant difference in on all data we studied. We suggest that neuromusculary
functions of the patients medicated by metoclopramide and neuromusculary blocking agents should be monitorized during
general anesthesia.

Yazar Bilgileri
1. Yazar
Yazar Adı: 
Hüsamettin KEŞKÜŞ
Yazar Üniversitesi: 
İstanbul Üniversitesi
Yazar Fakültesi: 
Cerrahpaşa Tıp Fakültesi
Yazar Anabilim Dalı: 
Anestezi ve Reanimasyon
2. Yazar
Yazar Adı: 
Ziya SALİHOĞLU
Yazar Ünvanı: 
Doktor
Yazar Üniversitesi: 
İstanbul Üniversitesi
Yazar Fakültesi: 
Cerrahpaşa Tıp Fakültesi
Yazar Anabilim Dalı: 
Anestezi ve Reanimasyon
Yazar E-posta: 
zsalihoglu@yahoo.com
Makale Künye Bilgisi
Makalenin Yayımlandığı Dergi: 
Cerrahpaşa Tıp Dergisi
Makale Yayın Yılı: 
2007
Cilt/Sayı: 
38
Sayı: 
1
Sayfa Aralığı: 
16-20
PDF Dosyası: 
application/pdf iconarastirmax_1065_pp_16-20.pdf
Makalenin Yayınlandığı Web Sitesindeki Linki: 
Makaleyi Dergi Web Sitesinden İndirin
Referanslar: 

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MH. Influence of metoclopramide on plasma
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Br J Anaesth 1999; 82: 542-545.
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mivacurium-induced neuromuscular blockade in
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5. Ostergaard D, Jensen FS, Jensen E, et al. Mivacurium-
induced neuromuscular blockade in patients
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6 Naguib M, Daoud W, el Gammal M, et al. Enzymatic
antagonism of mivacurium-induced neuromuscular
blockade by human plasma cholinesterase.
Anesthesiology 1995; 83: 694-701.
7. Nava-Ocampo AA, Velazquez-Armenta Y, Moyao-
Garsia D, et al. Meta-analysis of the differences in
the time to onset of action between rocuronium
and vecuronium. Clin Exp Phamacol Physiol 2006;
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8. Wierda JM, Hommes FD, Nap HJ, van den Broek
L. Time course of action and intubating conditions
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Anaesthesia 1995; 50: 393-396

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