SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF CEFPODOXIME PROXETIL AND AMBROXOL HYDROCHLORIDE IN TABLET DOSAGE FORM

Yayının 2. Dildeki İsmi: 

Dergi Adı: 

Yayın Yılı: 

  • 2012

Cilt: 

  • 1

Sayı: 

  • 3

Yayın Dili: 

  • İngilizce

Yazar Bilgileri: 

Abstract (2. Language): 

Cefpodoxime Proxetil is 3rd generation cephalosphorin and Ambroxol hydrochloride is mucolyti expectorent. The combination formulation is used for the treatment of the chronic bronchitis,COPD,respiratory tract infection. The new, simple, accurate and precise UV spectrophotometric methods have been developed and validated for the simultaneous determination of Cefpodoxime Proxetil(CPD) and Ambroxol hydrochloride(AMB) in their combined dosage forms. Method is based on simultaneous equation method using two wavelengths, 235 nm pünax of CPD) and 248 nm (^max of AMB). Methanol was the solvent used in this method. Cefpodoxime showed linearity in the range of 9-27 ^g/ml and Ambroxol showed linearity in the range of 8-32 ^g/ml in this the method. Method was validated statistically and recovery studies were carried out. Method was found to be accurate, precise and reproducible. This method was applied to the assay of the drugs in marketed formulation, which were found in the range of 98.0% to 102.0% of the labeled value for both Cefpodoxime and Ambroxol. Hence, the methods herein described can be successfully applied in quality control of combined pharmaceutical dosage forms.

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Referanslar: 

1. Maryadele
J
O Neil. The Merck Index: An Encyclopedia of chemicals, drugs and biological. 14th ed. Merck Research Laboratories, Merck and Co., Inc, Whitehouse station, New Jersey 2006: 319.
2. Brunton
LL
, Goodman and Gilman's The Pharmacological Basis of Therapeutics, 11th Edn, The MC Graw Hill publishing company limited, New Delhi, 2005, pp 1105-1106
3. Maryadele JO Neil. The Merck Index: An

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